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KMID : 1102220190380040414
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Kidney Research and Clinical Practice
2019 Volume.38 No. 4 p.414 ~ p.426
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The role of oxidative stress and hypoxia in renal disease
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Honda Tomoko
Hirakawa Yosuke
Nangaku Masaomi
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Abstract
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Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system induces oxidative stress. Oxidative stress, a critical contributor to tissue damage, is well-known to be associated with various diseases. The kidney is susceptible to hypoxia, and renal hypoxia is a common final pathway to end stage kidney disease, regardless of the underlying cause. Renal hypoxia aggravates oxidative stress, and elevated oxidative stress, in turn, exacerbates renal hypoxia. Oxidative stress is also enhanced in chronic kidney disease, especially diabetic kidney disease, through various mechanisms. Thus, the vicious cycle between oxidative stress and renal hypoxia critically contributes to the progression of renal injury. This review examines recent evidence connecting chronic hypoxia and oxidative stress in renal disease and subsequently describes several promising therapeutic approaches against oxidative stress.
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KEYWORD
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Hypoxia, Hypoxia-inducible factor, Nuclear factor erythroid 2-related factor 2, Oxidative stress, Renal insufficiency, chronic
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